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Title: Animal models of intraventricular haemorrhage and post-haemorrhagic ventricular dilatation
Author: Aquilina, Kristian
ISNI:       0000 0004 2742 5981
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2012
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Continuing improvements in neonatal care have allowed significant progress in the clinical outcome of prematurity, with improvement t in both survival and neurological outcome. Although the incidence of intraventricular haemorrhage associated with prematurity has been lowered, it still represents a significant source of neurological morbidity. Several management strategies have attempted to reduce the neurological impact of IVH and its progression to post-haemorrhagic ventricular dilatation (PHVD). Studies have evaluated the impact of serial withdrawal of cerebrospinal fluid (CSD) by lumbar puncture, fontanelletap or through a ventricular access device, yet none of these interventions have reduced progression to PHVD. The use of agents that reduce production of CSF have actually led to worse clinical outcomes for unclear reasons. A new technique involving intraventricular fibrinolysis, drainage and irrigation, while not reducing the need for CSF diversion, has improved cognitive outcome at 2 years.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available