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Title: Ultrasonographic features of carotid plaques : the value in patients with asymptomatic carotid disease
Author: Sabetai, Michael M.
ISNI:       0000 0004 2737 4934
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2007
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High-resolution ultrasound has become the primary tool in the investigation of patients with atherosclerotic carotid disease. Apart from defining the degree of stenosis non-invasively, it provides valuable information about the features of the carotid plaque. Overcoming the subjectivity of ultrasonographic carotid plaque characterisation is essential if this is to be applied reliably in a multi-centre study. Computer-assisted plaque characterisation with B-mode image normalisation and its application under different settings has become an essential tool for a meaningful comparison of carotid plaque ultrasonographic features with risk factors for atherosclerosis and ultimately incidence of ischaemic stroke. The aim of this thesis was to identify the association of clinical and biochemical risk factors, ultrasonographic carotid plaque characterisation and neuroimaging of the brain by means of CT-brain scan with the incidence of ischaemic stroke and cardiac mortality in patients with asymptomatic carotid stenosis. These risk factors may help identify a vulnerable carotid plaque and patients at increased risk for stroke. The ultrasonographic features of the vulnerable carotid plaque were identified in three cross-sectional studies and subsequentiy applied in a prospective study of asymptomatic carotid stenosis with ischaemic stroke and cardiac death as the primary end-points. Hypoechoic plaques were associated with a large necrotic core on histology, increased prevalence of neurological ischaemic symptoms and increased prevalence of embolic silent CT-brain infarcts.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available