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Title: Glial pathology in Parkinson's disease : focus on microglia
Author: Croisier, Emilie
ISNI:       0000 0004 2737 4256
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2007
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This thesis addresses the role of microglia and the concept of ^neuroinflammation' in Parkinson's disease (PD) using clinically well-characterised post-mortem human brain tissue. The first part of the project employs established immunohistochemical markers for defining microglial activation and PD-related protein aggregation and attempts to define the disease-specificity of the microglial response in PD. The results presented reconcile earlier conflicting reports using these markers and highlight the inadequacy of common microglial markers to fully characterise these cells in disease. These findings are significant to the interpretation of human imaging and animal models of PD, as well as future work on post-mortem tissue. Drawing from the conclusions of this work, the second part of the project involves the cell-type-specific analysis of a microarray profile of the PD brain and a protein-level backmapping of specific gene transcripts that are hypothesised to have a functional significance to immune-associated changes therein. Our findings support the hypothesis that neuroimmunological changes may play a significant role in PD progression, expand upon the traditional view of microglia as the primary effector cell of the brain's immune defence and raise more questions into how the brain's intrinsic immune response pathways can be adapted to slow or even prevent PD progression.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available