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Title: Obstructive Sleep Apnoea: An estimation of the prevalence in Northern Ireland and investigation of cardiovascular physiological parameters, apnoea/hypopnoea events, arousals and CPAP treatment
Author: McManus, Brenda
ISNI:       0000 0004 2736 7400
Awarding Body: University of Ulster
Current Institution: Ulster University
Date of Award: 2012
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There have been many studies investigating the effect of obstructive sleep apnoea (OSA) on the cardiovascular system, but there are only a few which attempt to correlate these findings to arousals and examine whether continuous positive airway pressure (Cl' AP) treatment is an effective long-term treatment in patients with mild, moderate and severe OSA. The overall aim of this study was to examine these parameters in detail, but also as sleep services in Northep; Ireland are under , ." - - enormous pressure to diagnose, treat and review patients suspected as having OSA, an assessment of the application of the Berlin Questionnaire as a screening tool for use by general practitioners was explored .. This programme of research involved a review of literature which identified several research questions to address inconsistent outcomes with respect to the alteration in cardiovascular markers, following apnoea/hypopnoea events, arousals and the effects of Cl' AP treatment in subjects with OSA. As a result microanalysis of cardiovascular data was performed during five consecutive apnoea/hypopnoea events and compared at early apnoea (EA), onset of apnoea or hypopnoea event and late apnoea (LA) immediately preceeding the onset of arousal. The second output from this thesis was the examination of the effect of 6 weeks and 6 months Cl' AP in subjects with OSA, on apnoea/hypopnoea index (AHI) and Arousal Index (Arl) over a range of cardiovascular markers. The inclusion of data on daytime sleepiness and quality of life was also collected as indicators of improvement in performance, mood, concentration and lifestyle. The third output of this thesis was the application and validation of the Berlin Questionnaire, to help clinicians filter referrals to sleep clinics, improve diagnosis treatment times and prevent further cardiovascular complications. An estimation of the prevalence of OSA in Northern Ireland in a selected population of adults was calculated from the results.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available