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Title: Chromatin modification contributes to senescence associated proliferation arrest
Author: Nelson, David Martin
ISNI:       0000 0004 2736 5632
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2012
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Senescence is a state of permanent proliferation arrest that normal cells undergo in response to shortened telomeres, oncogenic activation and other sources of cellular stress, thus restricting the replicative capacity of impaired or damaged cells. As such, senescence provides a potent mechanism of tumor suppression, but has also been implicated in organismal aging. Senescence is accompanied by profound chromatin remodeling, which reinforces several important features of the senescence program. Consequently, there is considerable interest in elucidating precisely how chromatin structure influences senescence. In the present work, I set out to investigate the role of the H4K20me3 histone modification in senescence, as the mark has been implicated in aging and is commonly lost in human cancers.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Q Science (General)