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Title: Studies towards a total synthesis of tagetitoxin
Author: Pearce, Christopher
ISNI:       0000 0004 2736 1914
Awarding Body: University of East Anglia
Current Institution: University of East Anglia
Date of Award: 2013
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Tagetitoxin is a phytotoxin produced by the bacterium Pseudomonas syringae pv. tagetis. It is a selective inhibitor of RNA polymerase III in eukaryotic cells and RNA polymerase in bacteria. Since its initial isolation and partial characterization, more than thirty years have passed without a fully characterized structure for tagetitoxin. While much research has been carried out on the biological aspects of tagetitoxin, particularly with interests towards its activity as an inhibitor of RNA polymerase, very few published works are available from a synthetic perspective. In this thesis several promising synthetic intermediates towards the goal of tagetitoxin were synthesized. Herein the previous work related to the biology and synthetic studies of tagetitoxin and the recent studies conducted in the group towards a total synthesis of the molecule is described.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available