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Title: The use of Raman spectroscopy for the intra-operative assessment of axillary lymph nodes in breast cancer
Author: Horsnell, Jonathan
ISNI:       0000 0004 2735 3906
Awarding Body: Cranfield University
Current Institution: Cranfield University
Date of Award: 2012
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Breast cancer remains a significant cause of morbidity and mortality. Assessment of the axillary lymph nodes is part of the staging of the disease. Advances in surgical management of breast cancer have seen a move towards intra-operative lymph node assessment that facilitates an immediate axillary clearance if it is indicated. Raman spectroscopy, a technique based on the inelastic scattering of light, has previously been shown to be capable of differentiating between normal and malignant tissue. These results, based on the biochemical composition of the tissue, potentially allow for this technique to be utilised in this clinical context. The aim of this study was to evaluate the facility of Raman spectroscopy to both assess axillary lymph node tissue within the theatre setting and to achieve results that were comparable to other intra-operative techniques within a clinically relevant time frame.
Supervisor: Stone, Nicholas; Chan, H. Y. Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available