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Title: Dynamics of absence seizures
Author: Benjamin, Oscar
ISNI:       0000 0004 2732 9973
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2011
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We develop techniques and models for analysing and understanding idiopathic generalised epilepsy, and absence epilepsy in particular. We present techniques for analysing the electroencephalogram of patients with idiopathic generalised epilepsy, having spike and wave discharges. The techniques may have clinical applications and can help to further our understanding of the physiological mechanisms involved in spike and wave discharges and absence seizures. We introduce a new model based on the hypothesis that spike and wave discharges initiate through a transition in a multistable system. The emphasis of the model is in understanding how network structure could relate to the pathology of epilepsy, which is explored with application to human electroencephalogram data. We present evidence to support the hypothesis that changes in network connectivity are a factor in the pathology of epilepsy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available