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Title: The relationships between human pineal function and thermoregulation at rest and during exercise
Author: Marrin, Kelly
ISNI:       0000 0004 2732 9017
Awarding Body: Liverpool John Moores University
Current Institution: Liverpool John Moores University
Date of Award: 2012
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The pineal gland and its secretory product, melatonin, have a fundamental role in the control of human circadian rhythms. Most studies have investigated circadian variation in Pineal function at rest, and an inverse relationship between melatonin and core temperature rhythms has been reported. Nevertheless, there is a lack of research on these relationships during exercise. Such research is important for ascertaining how much exercise 'masks' endogenous secretion of melatonin as well as for explaining how exercise itself influences the circadian system in humans. The studies in this thesis are designed to help fill this dearth of knowledge in exploring relationships between circadian variation in melatonin 'and core body temperature at- rest and during exercise Because most past studies have involved small sample sizes, meta-analytical methods were employed in study 1 to determine the precise effects of exogenous melatonin on core body temperature and explore the impact of various moderating variables on this temperature change. Following an extensive literature search, 33 studies involving a total of 193 participants and 429 separate melatonin ingestions were meta-analysed. The weighted mean (95% CI) reduction in body temperature was found to be 0.21 (0.18-0.24) DC. Gender and time of day of melatonin ingestion had negligible effects on this reduction (P>0.05). A linear, but shallow, dose- response relationship between melatonin and temperature reduction of 0.013 within the dose range of 0.03 to 10 mg (P
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available