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Title: Polyurethane as a substrate for cell transplantation in the treatment of age related macular degeneration (AMD)
Author: Alias, Eliesmaziah
ISNI:       0000 0004 2734 4460
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2011
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Introduction: Age-related macular degeneration (AMD) results in the deterioration of the retinal pigment epithelial (RPE) layer under the macula. A potential surgical treatment involves the replacement of the diseased RPE cells with healthy cells. Clinically, this requires identification of the appropriate cells to use and the optimal substrate for use as a transplant vehicle. The material under investigation was polyurethane (PU) and ways to manufacture porous PU were explored. Iris pigment epithelium (IPE) is derived from the same embryonic origin as RPE and has been shown to have several of the same functions. IPE can be harvested more easily than RPE. The aim of this study was to compare the behaviour of primary bovine RPE (bRPE), IPE (bIPE) and human RPE (hRPE) cultured on PU membranes with the objective of optimising the cell/substrate combination for transplantation. Morphology and functionality of the cells attaching on the membranes were also evaluated. Methods: The PU used in this study were Z3Ai and Z9Ai (b9'" Biomer Technology Ltd.) membranes with thickness
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral