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Title: The synthesis of mycolic acids
Author: Don-Lawson, Chioma Donubari
ISNI:       0000 0004 2732 3651
Awarding Body: Bangor University
Current Institution: Bangor University
Date of Award: 2012
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This project consists of three parts. In the first part the synthesis of two mycolic acid diastereomers (I and II) was achieved, thereby completing the full range of the cisdicyclopropane a-mycolic acid diastereomers. The second part comprised the development of a new method for the synthesis of the a-alkyl-B-hydroxy fragment of mycolic acids; two novel routes that involved fewer steps ted using L-malic as starting material. The first route which was via diethyl malate was achieved in fewer steps without a significant reduction in percentage yield. The second route via dimethyl malate was also completed successfiilly. Finally, a model cord facto III of a B-hydroxy carboxylic acid without an a-alkyl chain was prepared.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available