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Title: The synthesis of pH dependant macrocycles for switchable anion recognition
Author: Nesbit, William
ISNI:       0000 0004 2730 9024
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2012
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This thesis is concerned with the synthesis of a range of pH switchable macrocycles and their ability to bind anions. Chapter 1 provides an introduction to anion recogntion within supramolecular chemistry and introduces switchable anion recognition and potential application of such. Chapter 2 describes the optimisation of synthesis of a designed pH macrocyclic receptor functionalised with benzyl groups. This revealed that the cavity size was too stable for efficient switching. This led us into Chapter 3 whereby the synthesis of a series of pH switchable macrocycles of varying cavity size facilitated efficient switching and recognition of a range anionic guests. Chloride proved to be an excellent guest which led us to investigate the macrocycles’ ability to transport HCl across a synthetic membrane. The results of this led into Chapter 4 whereby we attempted to optimise the transmembrane transport properties of these system types by improving solubility and also testing some acyclic systems. The conclusions of this showed that the systems required more work to be effective HCl co-transporters.
Supervisor: Bloodworth, Sally Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry