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Title: Novel multi-metallic luminescent complexes towards dual-functional cellular and therapeutic applications
Author: Balasingham, Rebeca Glory
ISNI:       0000 0004 2735 2188
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2012
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A series of novel multi-metallic luminescent Au(I) and Re(I) complexes have been synthesised targeting functionality as cellular imaging and/or therapeutic agents. Both the ligands and their complexes have been characterised by a variety of spectroscopic and spectrometric techniques. Several complexes were also characterised by X-ray crystal diffraction and/or elemental analysis. In both chapters two and three the modulation of the luminescent properties of a series of mono- and di-metallic [Re(CO)3(N^N)L]+ type complexes bearing functionalised alkyl chains by hydrophobically driven, intra- and intermolecular conformational changes is reported. Additionally, the first application of di-metallic Re(I) complexes in cellular imaging is reported with specific localisation in the nucleoli or ER and Golgi apparatus. In both chapters four and five the synthesis of novel mono- and di-metallic Au(I) complexes is reported. Several complexes demonstrated cytotoxicity as well as compartemental localisation in cellular imaging demonstrating their potential as dual-functional cellular imaging and/or therapeutic agents. As an extension to the work discussed in Chapters two to five, the synthesis of novel multi-metallic luminescent complexes is reported in Chapter six. For the tri-hetero-metallic complex incorporating Au(I) and Re(I) units, cytotoxicity towards four cancer cell lines and non-specific localization throughout the entire cell is described.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry