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Title: T-cell polarisation by dendritic cells : a role for Notch ligands?
Author: Worsley, Alan G. F.
ISNI:       0000 0004 2728 7152
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2009
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The intention of the work described in this thesis was to identify whether the Notch signalling pathway is utilized by antigen presenting cells in order to influence CD4+ adaptive immune responses. The notion that Notch proteins may be involved in polarising CD4+ T cells is relatively recent and most of the work that had been done in this area so far has concentrated on the consequences of Notch signalling within T cells. In contrast, the work that I have done has focussed on Notch ligand expression by antigen presenting cells and addresses the question whether Notch signalling is a redundant, necessary or irrelevant tool in the arsenal of antigen presentation.
Supervisor: MacDonald, Andrew. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Biology ; Immunology