Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.562384 |
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Title: | Direct arylation of thiazoles | ||||||
Author: | Turner, Gemma L. |
ISNI:
0000 0004 2728 4357
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Awarding Body: | University of Edinburgh | ||||||
Current Institution: | University of Edinburgh | ||||||
Date of Award: | 2009 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
An introduction to the thiazole ring system is presented together with a detailed, but non-exhaustive review of the rapidly emerging area of palladium-mediated directed arylation. The direct arylation of thiazole is also discussed together with our attempts to improve the established methods. A high-yielding, mild protocol has been developed for the functionalisation of the most electron-rich carbon-hydrogen bonds in a number of heterocyclic ring systems, this represents the first example of a C-H activation reaction being accomplished in aqueous media and allows access to a diverse range of functionalised aryl heterocycles. In addition, work towards functionalisation of the thiazole C4 position is described. A number of different approaches are discussed and our endeavors are recorded.
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Supervisor: | Greaney, Michael F. | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.562384 | DOI: | Not available | ||||
Keywords: | Chemistry ; Organic Chemistry | ||||||
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