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Title: Mathematical modelling of spatially coherent transcription
Author: Swingland, James Thomas
ISNI:       0000 0004 2728 5448
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2012
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Genetics and epigenetics are widely expected to revolutionise our understanding of health and disease. However any attempt to extract relevant information from noisy data requires a combination of modelling and statistical techniques. Given the number of genes and the complexity involved in the genome, sophisticated methods will be needed to properly capture the information that is contained. Many mechanisms and variables can affect and control the expression of a gene. In this thesis, it is specifically spatially coherent variations in transcription which are investigated. Several different areas were examined, producing a broad set of results. Important findings include the demonstration of spatial coherence as the result of epigenetic effects, the creation and validation of a technique to detect spatial coherence, and the extension of spatial modelling to epigenetic data. Other important results include the detection of spatial coherence variation due to confounding variables (PMI and neuronal concentration) and the development of new spatial modelling techniques. The results indicate that spatial modelling provides a useful approach to investigating unusual and unknown aspects of epigenetic and transcriptional regulation.
Supervisor: Turkheimer, Federico Sponsor: Medical Research Council
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral