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Title: Quantitative asymmetric reaction kinetics
Author: Rushworth, Philip John
ISNI:       0000 0004 2723 8430
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2011
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The comparison of catalysts for producing chiral materials is of vital importance in the improvement of reaction scope and efficacy. Here we describe a new method of analysing the kinetics of the stereodetermining steps in asymmetric reactions by performing ligand/catalyst competition experiments against an internal standard and measuring the enantiomeric excess obtained at a variety of ratios of ligand/catalyst to internal standard. From these enantiomeric excess measurements, we can establish the relative rate of reaction between the ligand/catalyst systems and the internal standard, allowing us to make indirect comparisons of the rates at which the ligands/catalysts perform the reaction. Here we take this method and apply it to three common synthetic procedures: the Sharpless asymmetric dihydroxylation, the asymmetric Michael addition of malonates to nitroalkenes and palladium catalysed asymmetric allylation reaction.
Supervisor: Not available Sponsor: Engineering and Physical Sciences Research Council (EPSRC)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry