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Title: Asymmetric transfer hydrogenation reductions using tethered ruthenium (II) catalysts
Author: Parekh, Vimal
ISNI:       0000 0004 2723 8350
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2011
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By asymmetric transfer hydrogenation, substituted quinolines, which are generally regarded as challenging substrates for reduction, were successfully converted into tetrahydroquinolines using "tethered" Ru(II) and "tethered" Rh(III) complexes in formic acid/triethylamine. An ether-linked "tethered" catalyst was successfully synthesized through a sequence that avoids the use of a Birch reduction for the formation of a 1,4-cyclohexadiene moiety. The ether link is incorporated between the basic amine of the ligand and the η6- arene ring, giving results comparable to the alkyl-"tethered" complexes. N-alkylated complexes containing a straight-chain substituent attached to a hydroxyl, ether or ester function can act as effective catalysts for the reduction of ketones, and also contains the required functionality for attachment of the catalyst to a heterogeneous support.
Supervisor: Not available Sponsor: Engineering and Physical Sciences Research Council (EPSRC) ; Dr. Reddy's Laboratories
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry