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Title: Comparative neurotranscriptomics in mammals and birds
Author: Belgard, Tildon Grant
ISNI:       0000 0004 2722 0230
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2011
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In this thesis I apply new sequencing technologies and analytical methods derived from genomics and computer science to the neuroanatomy of gene expression. The first project explores characteristics of gene expression across adult neocortical layers in a representative mammal – the mouse. Amongst the thousands of genes and transcripts differentially expressed across layers, I found common functional characteristics of genes that define certain layers, candidate cases of isoform switching, and over a thousand apparent long intergenic non-coding RNA transcripts. The second project compares patterns of gene expression in the structurally diverged adult derivatives of the pallium in mice and chickens. Overall, gene expression levels were moderately correlated between the two species. While expression patterns of ‘marker’ genes were only poorly conserved in these regions, there nevertheless was significant conservation of cross-species marker genes for homologous structures, cell types and functionally analogous regions. Many aspects of these data from both projects can now be easily browsed and searched from custom-built web interfaces. In addition to generating unprecedented genome-wide resources for the neuroscience community to explore the functional and structural dimensions of gene expression amongst different pallial regions in mammals and birds, this work also provides new insights into the widespread evolutionary shuffling of adult marker gene expression.
Supervisor: Ponting, Chris P. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Life Sciences ; Genetics (life sciences) ; Neuroscience ; Bioinformatics (life sciences) ; Biology ; Bioinformatics (biochemistry) ; Physiology and anatomy ; Biochemistry ; Evolution (zoology) ; Zoological sciences ; Medical sciences ; Anatomy ; Biology (medical sciences) ; Neuroscience ; Neurogenetics ; Molecular genetics ; Mathematical genetics and bioinformatics (statistics) ; Bioinformatics (technology) ; comparative neurotranscriptomics ; neuroanatomy ; comparative neuroanatomy ; RNA-seq ; transcriptome ; sequencing ; mammals ; birds