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Title: Phytocannabinoid effects on feeding
Author: Farrimond, J. A.
ISNI:       0000 0004 2727 1687
Awarding Body: University of Reading
Current Institution: University of Reading
Date of Award: 2011
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This project determined whether non-A'tetrahydrocannabinol phytocannabinoids (non-L'l9THC pCBs) had any effect on feeding patterns in rats and, if so, to characterise such effects. It is well described that L'l9THC administration induces cannabinoid type 1 receptor-mediated hyperphagia by increasing short- term food consumption due to reductions in the latency to feed. Yet, at the outset of this work there was little data available concerning whether or not other pCBs had any effectJs on feeding patterns. Using a pre-satiated paradigm, groups of male rats were administered one of either a range of purified pCBs, two standardised cannabis extracts, two extract analogues or a synthetic L'l9THC. Feeding microstructure data were then examined and analysed for hourly intakes and critical meal parameters. It has been demonstrated for the first time that cannabinol administration increases appetitive (behaviours which govern the latency to feed) and consummatory behaviours (those which control the length and size of meals) and the amount of food consumed. Also for the first time, L'l9THC-mediated effects on meal patterns have been observed. Furthermore, cannabidiol has been shown to induce reductions in food intake over a four hour period. By contrast, cannabigerol and fl9tetrahydrocannabivarin were ineffective feeding modulators in this paradigm. Given the lack of psychotropic side effects observed following the administration of the pCBs, both here and in reported literature, these data suggest that cannabinol and cannabidiol could form the basis of two therapeutic agents to control feeding patterns without psychotropic side effects. These data form the basis for future experiments, potentially clinical, in the field.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available