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Title: Monitoring cell and tissue damage during ablation by high-intensity focussed ultrasound
Author: Nandlall, Sacha D.
ISNI:       0000 0004 2726 5818
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2011
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High Intensity Focussed Ultrasound (HIFU) ablation is a promising technology for the non-invasive, targeted treatment of certain types of cancer. The technique functions by subjecting tumours to a cytotoxic level of intense, localised heating, while leaving the surrounding tissue unharmed. However, a number of limitations in the available HIFU treatment monitoring methods are currently hampering the effectiveness and clinical adoption of the therapy. This work aims to develop improved metrics of HIFU-induced biological damage that are specifically suited to monitoring and controlling HIFU ablation. Firstly, an optical method that enables straightforward quantification of thermal damage in protein-embedding hydrogels is developed. Secondly, hydrogels embedded with different cell lines are used to assess the performance of common temperature-based metrics of cell death across a range of HIFU-relevant conditions. Finally, a novel, passive acoustic detector designed for the real-time monitoring of HIFU-induced tissue damage is proposed. The detector is shown to predict lesioning with over 80% accuracy in regimes that are very likely to create lesions (60 J of acoustic energy or more), with an error rate of less than 6% for exposures that are too short to cause lesioning (up to 1 s long). The proposed detector could therefore provide a low-cost means of effectively monitoring clinical HIFU treatments passively and in real time.
Supervisor: Coussios, Constantin-C. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Technology and Applied Sciences ; Medical Engineering ; Biomedical engineering ; Engineering & allied sciences ; Medical sciences ; Oncology ; High Intensity Focussed Ultrasound (HIFU) ; ultrasound ; biomedical engineering ; cancer therapy ; ablation