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Title: Tumour cell-bone cell interactions in breast cancer bone metastases : mechanisms and effects of therapies
Author: Brown, H. K.
ISNI:       0000 0004 2723 9978
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2012
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Among women, breast cancer is the most common malignancy and represents the second leading cause of the high mortality rate for cancer patients. At least 70% of breast cancer patients with advanced disease develop bone metastases and death is often due to the formation and progression of metastatic lesions (Coleman, 2001). Over the past decades there has been great progress in the treatment of early breast cancer, but the current inability to cure metastatic disease emphasises the need for new treatment strategies for advanced cancer patients. The investigation of bone metastases in humans is greatly impeded due to the lack of available biopsies. Hence translational research using preclinical models plays an important role in identifying new treatment targets.
Supervisor: Holen, Ingunn Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available