Use this URL to cite or link to this record in EThOS:
Title: Developments in low dose combined oral contraception : modifications of the pill free interval
Author: Sullivan, Helen Jane
ISNI:       0000 0004 2724 2237
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 1996
Availability of Full Text:
Access from EThOS:
Since the introduction of the combined oral contraceptive the dosage of both the oestrogen and progestogen components have been reduced to try to eliminate unwanted effects. Preparations with 20μg ethinyl oestradiol doses appear to inhibit ovulation effectively but allow appreciable ovarian activity. There have been problems also with unscheduled vaginal bleeding. Three ovulation inhibition studies were performed in which women were monitored over a pre treatment control cycle, three treatment cycles and a further cycle post treatment. Ovarian activity was monitored by ovarian ultrasound and hormone assays. Data on bleeding patterns and side effects also were recorded. The first study was a randomised double blind trial of the effect of 23 and 21 day administration of 20μg ethinyl oestradiol and 75μg gestodene. 20 women were allocated to 21 days active treatment and 22 women to receive 23 days active treatment. The women with the shorter pill free interval, had less ovarian activity in terms of serum oestradiol and follicle development. In addition there was less breakthrough bleeding. The 21 day preparation was launched in Europe in 1996.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available