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Title: Physical and clinical assessment of recent advances in positron emission tomography
Author: Jakoby, Bjorn W.
ISNI:       0000 0004 2719 0369
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 2011
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Positron Emission Tomography has experienced several advances in the last decade. This thesis assesses the recent developments in PET scanners: New, fast scintillators, higher resolution detectors, fully 3D imaging and increased sensitivity, iterative reconstruction algorithms with implementation of point spread function modelling and time-of-flight. The physical performance characteristics of three multi-ring and one panel based configuration were quantified using phantom experiments. The clinical impact of increased sensitivity was explored. Figures of merit to assess image quality were established and a method to optimise reconstruction algorithms for signal-to-noise was developed and applied. The improvements of implementing point spread function modelling into image reconstruction were investigated and quantified. The implementation of time-of-flight in addition to point-spread-fiinction modelling was explored in substantial detail and compared. Experimental results were obtained and the clinical impact of time-of-flight was assessed. In a final investigation, the panel based PET scanner design was successfully applied in veterinary medicine.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available