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Title: Hyperpolarised ³He lung MRI with compressed sensing
Author: Ajraoui, Salma
ISNI:       0000 0004 2724 5147
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2011
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Hyperpolarised (HP) gas MRI is a non-invasive technique for high spatial and temporal resolution imaging of the lung air spaces, providing both functional and anatomical information. The major technical challenges facing this technique are the non sustainability of gas polarisation inside the lung due to RF pulses, T 1 decay due to paramagnetic 02 and short breath-hold times. There is also a motivation for acquisition of most of the information needed for multi-parametric calculation, from the same scan and with a single dose of 3He gas. In this thesis, the application of Compressed Sensing techniques to the acquisition and reconstruction of hyper polarised 3He lung MR images was investigated. New methods were also developed to optimise the sampling strategies and improve the Compressed Sensing algorithm by incorporation of prior knowledge to achieve higher reduction factors for HP 3He images. Additionally, a new sequence was implemented to acquire ventilation images, ADC, T2* and flip angle maps in a single scan from the human lungs with inhaled 3He at 3 T.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available