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Title: Cardio-respiratory recovery variables in healthy and heart failure populations : responses following exercise and specific interventions
Author: Donovan, Gabrielle Clare
ISNI:       0000 0004 2719 9814
Awarding Body: Brunel University
Current Institution: Brunel University
Date of Award: 2011
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Heart rate (HR) recovery reflects the complex inter-play between the parasympathetic I sympathetic branches of the autonomic nervous system (ANS). Oxygen uptake (V02) recovery illustrates the oxygen debt post-exercise. Both reflect the body's ability to restore homeostasis following exercise stress, and are independent prognostic markers of all-cause mortality. The purpose of this thesis is to extend current knowledge on the HR and V02 recovery responses to acute and chronic exercise in asymptomatic and chronic heart failure (CHF) populations. Literature and methodological reviews highlighted disparities in previous research leading to mixed results and incompatibility between studies. The initial investigation, in an asymptomatic population, assessed different recovery and statistical protocols in order to provide a basis for comparison with previously published data. The reliability of HR and ]/02 recovery III CHF has not been investigated. Previous work suggested that both measures were reliable in healthy populations. Empirical work established meaningful differences in a sample CHF population in order to examine any changes following chronic exercise training. There are no data assessing changes in HR and ]/02 recovery responses to aerobic or resistance only exercise training, in CHF. Whilst HR and ]/02 recovery did not significantly change following either intervention, participants exercised for longer, at higher workloads, for similar recovery trends. Furthermore, associations between HR, ]/02 recovery and other cardio-pulmonary prognostic markers were found to normalise, comparing favourably with those found in asymptomatic populations. Little is known regarding HR and ]/02 recovery in patients implanted with left ventricular assist devices. The responses following acute and chronic implantation were investigated, resulting in very individual outcomes. The results support the use of HR and ]/02 recovery as adjunct measures in assessing myocardial recovery, in this novel patient group. In conclusion attenuated HR and ]/02 recovery, as known risk factors, should be regarded as important therapeutic exercise targets in patients with moderate to severe CHF.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available