Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554727 |
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Title: | Novel strategies for the construction of cyclic boronate esters and acids & novel aspects of furan chemistry | ||||||
Author: | Pryke, James A. |
ISNI:
0000 0004 2724 7855
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Awarding Body: | University of Sussex | ||||||
Current Institution: | University of Sussex | ||||||
Date of Award: | 2012 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
Methodology studies for cyclic boronate ester synthesis Figure i: Target molecules (see Abstract in pdf for image) Structures i,ii,iii represent a general depiction of cyclic boron-containing heterocyles targeted in this methodology study. These molecules will be made using a range of new organic pathways. A 1,3 nitrogen-boron relationship in selected structures will also be investigated due to its importance in pharmaceutical chemistry. In the pursuit of cyclic boranes a new method for the preparation of unsaturated ketones has been discovered, which utilises the boron chemistry outlined below. Figure ii: Reagents and Conditions: (a) tBuLi, B(OIPr)3, Et2O, -79 °C, 20 % (see Abstract in pdf for image) Novel aspects of furan chemistry It was found that the furan derivative vii, when treated with palladium salts, gave the bis-annulated benzene structure viii. This sequence gave rise to a novel method for the construction of aromatic rings. This reaction was tested on a range of substituted furans in order to examine the scope of this reaction. Figure iii: Reagents and Conditions: (a) Pd(OAc)2, K2CO3, MeCN, 80 °C, 25% (see Abstract in pdf for image).
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Supervisor: | Not available | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.554727 | DOI: | Not available | ||||
Keywords: | QD0241 Organic chemistry | ||||||
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