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Title: Structure-function studies of the retina using retinal imaging and multifocal electroretinography
Author: Wolsley, Clive
ISNI:       0000 0004 2721 9109
Awarding Body: University of Ulster
Current Institution: Ulster University
Date of Award: 2009
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In recent years there has been a great deal of interest in describing the relationships between the structure and function of the retina at a local level. Techniques such as the multifocal electroretinogram (mfERG) provide objective measures of localised retinal function and could provide new information about structure- function comparisons. Novel studies relating mfERGs with eo-localised structure and subjective function information have been undertaken in two ocular conditions, myopia and retinitis pigmentosa (RP). Measurements include peripheral resolution acuity, retinal thickness from optical coherence tomography (OCT), cone counts from confocal scanning laser ophthalmoscopy (CSLO) and ocular length at different eccentricities. In myopia where there is axial elongation of the eye, co-localised loss of mfERG function and reduced retinal cell density occur in regions where retinal laminar structure is thinned. This relationship is more evident in the peripheral retina rather than the central retina. In RP, where chronic deformation of the retina is likely, thinning of the photoreceptor layer and thickening of the inner retinal layers occurs. Only in some regions of the retina are these changes associated with a localised loss of retinal function. Preliminary data from images of the photoreceptor mosaic using CSLO suggests a strong correlation between co-localised cone counts and mfERG amplitude. These studies demonstrate a close association between changes in structure and function in myopia due to retinal stretching, but also suggest important underlying differences in myopic cell function. The structure- function relationship in RP is not always linear, but is dependent on retinal location and the precise nature of the measurements used. Empirical measures of cone density from retinal images could enhance evaluation of retinal structures in myopia and RP. Combining complementary measurements from ocular imaging and psychophysics with mfERG amplitude and timing demonstrates great potential for evaluating local retinal structure-function and function-function relationships in different eye conditions.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available