Use this URL to cite or link to this record in EThOS:
Title: Bioavailability and bioactivity of wholegrain components
Author: Keaveney, Edel M.
ISNI:       0000 0004 2721 2222
Awarding Body: University of Ulster
Current Institution: Ulster University
Date of Award: 2009
Availability of Full Text:
Access from EThOS:
Epidemiological evidence suggests that a diet rich in whole grains protects against the development of chronic diseases such as vascular disease. Whole grain fractions bran and aleurone are relatively good sources of to cop hero Is, trace minerals and methyl donors: folate, choline and betaine; components which may confer benefit through improving antioxidant status and lowering plasma homocysteine. The aim of this work was to evaluate the uptake of to cop hero Is and methyl donors from wheat bran and aleurone fractions, and to assess the effects of longer-term consumption of aleurone-enriched foods on plasma status of to cop hero Is, methyl donors, trace minerals and total homocysteine. A postprandial study assessed the effects of consumption of minimally processed wheat bran and aleurone fractions and results demonstrated that plasma betaine was significantly increased following consumption of both fractions; however plasma tocopherols, folate, and choline were unaffected. A four-week parallel intervention study which assessed the effects of consumption of aleurone-enriched bread and cereal showed significant increases in plasma betaine and significant decreases in plasma total homocysteine, however, plasma tocopherols, trace minerals, folate and choline did not change. These results are relevant as an elevated plasma homocysteine concentration is an independent risk factor for heart disease and stroke, diseases which are a common cause of death in the UK. Previous studies have shown that high doses of supplemental methyl donors lower plasma total homocysteine; however, this research shows that foods enriched with aleurone, a novel natural food ingredient rich in methyl donors, also have the potential to lower plasma total homocysteine. This research further adds to the knowledge on how whole grain fractions are beneficial to health, and may have implications for the development of novel grain-based food products.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available