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Title: Development of new fluorescent silica and multifunctional nanoparticles for bio-imaging and diagnostics
Author: Lemelle, Arnaud
ISNI:       0000 0004 2715 5758
Awarding Body: Cranfield University
Current Institution: Cranfield University
Date of Award: 2011
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Silica nanoparticles are effective fluorophore carriers with high potential in imaging, diagnostics, and therapy. The particles are resistant to drastic change of environmental conditions (pH, temperature etc.) and insulate the dyes so as to protect them from photobleaching. Silica chemistry is also versatile and affords an easy modification of the particle composition and surface to integrate targeting ligands or to integrate other nanoparticles. Regardless of their advantages, there exists a lack of dye diversity in the literature that is connected to a low affinity for potential tools for biology and medicineThis thesis describes the development of an alternative method for the synthesis of fluorescent silica nanoparticles and their modification to incorporate iron oxide and gold. cont/d.
Supervisor: Morgan, Sarah ; Tothill, I. E. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Nanomedicine ; imaging ; sol-gel ; nanoparticles ; silica ; iron oxide, ; gold