Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552360 |
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Title: | The synthesis and biological evaluation of d-myo-inositol 1,4,5-trisphosphate receptor ligands | ||||||
Author: | Keddie, Neil S. |
ISNI:
0000 0004 2719 1804
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Awarding Body: | University of St Andrews | ||||||
Current Institution: | University of St Andrews | ||||||
Date of Award: | 2010 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
The intracellular second messenger InsP₃ is a vital molecule in the regulation of Ca²⁺ signalling. Ca²⁺ mediates a wide range of cellular activities from fertilisation and cell differentiation through to apoptoisis. Using X-ray crystal structure data and molecular modelling, a series of novel InsP₃ analogues were designed as selective InsP₃R-antagonists. Two novel synthetic routes have been developed for the synthesis of these analogues. The first route uses a Ferrier-II rearrangement to provide enantiopure inositol intermediates, whereas, the second route employs a diastereomeric resolution to obtain the enantiopure inositols. The successful synthesis of InsP₃ and a series of 5-position modified analogues are reported herein.
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Supervisor: | Conway, Stuart J. | Sponsor: | Biotechnology and Biological Sciences Research Council | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.552360 | DOI: | Not available | ||||
Keywords: | d-myo-inositol ; Inositol ; d-myo-inositol 1,4,5-trisphosphate ; InsP3 ; InsP3 receptor (InsP3Rs) ; InsP3 receptor ligands ; Synthesis ; QP772.I5K4 ; Inositol phosphates--Synthesis ; Inositol phosphates--Derivatives--Synthesis | ||||||
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