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Title: Synthesis of D-myo-inositol 1,4,5-triphosphate analogues
Author: Bello, Davide
ISNI:       0000 0004 2715 6451
Awarding Body: University of St Andrews
Current Institution: University of St Andrews
Date of Award: 2007
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The cytosolic second messenger D-myo-inositol 1,4,5-trisphosphate (InsP₃), has the ability to mobilise Ca²⁺ from intracellular stores. Ca²⁺ controls a wide range of cellular processes, such as cell division and proliferation, apoptosis, fertilisation, gene transcription and muscle contraction. A number of potent InsP₃ receptor agonists are currently known; however, no selective InsP₃Rs antagonists have been reported to date. Using the X-ray crystal structure of the mouse type 1 InsP₃R, a range of analogues (below) has been designed with the intention of these compounds acting as competitive InsP₃Rs antagonists. The successful syntheses of these compounds are reported herein.
Supervisor: Conway, Stuart J. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QP517.C45B4 ; Second messengers (Biochemistry) ; Organic compounds--Synthesis