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Title: A biomechanical study of percutaneous vertebroplasty for burst fractures
Author: Lomoro, Pamela-Lulu
ISNI:       0000 0004 2714 7985
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2010
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Vertebral burst fractures are a significant health and economic concern worldwide. The optimal management of these types of fractures remains unknown. Current techniques for treating burst fractures carry a high risk of complications including neurological damage. Percutaneous vertebroplasty has become a pro~sing alternative procedure for the treatment of Osteoporotic spinal fractures. However, little is known about its effectiveness for the augmentation of burst fractures. The aim of this project was to investigate the biomechanical effectiveness of vertebroplasty as a primary intervention for the treatment of burst fractures with varying degrees of severity. Porcine thoracolumbar spines of varying fracture severity were augmented with PMMA cement. The mechanical stability of these specimens was determined dynamically with 2500 N of axial compression to a maximum of 100000 cycles. A control group of intact and of fractured-unaugmented specimens were also tested under the same conditions. The results show that there was an overall statistically significant difference in the dynamic stiffness means of augmented specimens in the different fracture groups (F (4, 44) =20.7, P < 0.05). The dynamic stiffness of the augmented specimens with the least fracture severity and that of the intact group were not significantly different over 100000 cycles of loading (P>0.05). This corresponded with a similar subsidence rate of 1.73 mm ± 0.69 SD and 1.80 mm ± 0.68 SD respectively. Conversely, the difference in the dynamic stiffness and subsidence rate between the intact and the augmented specimens of greater fracture severity was significant (P < 0.05). The results of this preliminary study indicate that the mechanical properties of the mild burst fracture can be significantly restored with vertebroplasty treatment to their intact levels. However, the technique does not restore the mechanical integrity of fractures with greater severity. The results of this study support recent clinical findings.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available