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Title: Model studies of reductase enzyme inhibition using hindered phenoxyl radicals
Author: Al-Malki, Fatima Khamis S.
ISNI:       0000 0004 2714 7619
Awarding Body: University of Sussex
Current Institution: University of Sussex
Date of Award: 2003
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The reactions of a number of unsaturated compounds with tri-t-butylphenoxyl, pentabromophenoxyl and pentachlorophenoxyl radicals (models for the tyrosyl phenoxyl centreso f reductasee nzymes)h ave been investigatedt o assessth e suitability of different unsaturated groups as potential inhibitors for the enzyme. To do this, we studied kinetically (by ESR and UVNIS) the reactions of the phenoxyl radicals with a number of unsaturated compounds to obtain rates of reaction for loss of the phenoxyl radicals. Compounds which have conjugated or cumulated unsaturation are more reactive than simple alkenes or ketones. These include azidotrimethylsilane, cyclopentadiene, styrene and methyl methacrylate. Product studies were carried out for reactions with azidotrimethylsilane and cyclopentadiene, which react relatively rapidly with the phenoxyl radicals. Cyclopentadiene gives adducts, azidotrimethylsilane gives the trimethylsilyl ether of the phenol. Molecules of these types thus have the potential to act as ribonucleotide reductase inhibitors, since the products will not readily be reoxidised to the phenoxyl radical in vivo
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available