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Title: Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach
Author: Murray, Alexandra M.
ISNI:       0000 0004 2718 5412
Awarding Body: University of Hull
Current Institution: University of Hull
Date of Award: 2011
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Treatment strategies for advanced malignancy remain limited in their success, despite major advances in the understanding of cancer aetiology and molecular biology. The incidence of many cancers, including melanoma, continues to rise, with a huge demand for therapies even if treatment goals are purely cytostatic. One particular therapeutic strategy is the metronomic (continuous and low) dosing of conventional chemotherapy. There is evidence to suggest that tumour vasculature is the main target of this dosing schedule resulting in an overall 'non specific' anti-angiogenic effect. It is now being studied in clinical trials alone and in combination with specific anti- angiogenic agents. This thesis had two main aims: firstly to investigate the additive or synergistic anti- endothelial effects of a number of conventional cytotoxic agents (Temozolomide, Paclitaxel, Vinorelbine, Etoposide, Carboplatin) in vitro given in a metronomic schedule in combination with a specific anti-angiogenic compound (Sorafenib) and a non-specific sompound (Combretastatin). The anti-proliferative, cytotoxic activities of the metronomic combinatorial schedules were assessed on microvascular endothelial cells and cancer cells usmg an MTT proliferation assay. Results confirmed significant (p
Supervisor: Maraveyas, Anthony ; Stanley, Paul R. ; Cawkwell, Lynn Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Medicine