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Title: Neural cardiovascular control during exercise : influence of sex and ovarian hormones
Author: Hartwich, Doreen
ISNI:       0000 0004 2715 5643
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2012
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Cardiovascular control during exercise results from three main mechanisms, namely central command (descending neural input), skeletal muscle afferent feedback (metabo - and mechanoreflex) and the arterial baroreflex. The studies outlined in this thesis sought to examine the potential sex- and ovarian hormone influences in neural cardiovascular control during exercise. It was observed that the activation of metabolically sensitive skeletal muscle afferents (i.e. muscle metaboreflex) by partial restriction of blood flow to the exercising skeletal muscle contributes to the exercise tachycardia via a reduction in cardiac baroreflex sensitivity from rest during dynamic exercise. Importantly, the magnitude of this metaboreflex-mediated reduction in cardiac baroreflex responsiveness was not different between men and women during the early and late follicular phases of the ovarian cycle. Baroreflex perturbation during dynamic exercise, by means of hypotensive and hypertensive stimuli to the carotid baroreceptors, revealed that baroreflex control of blood pressure was similarly maintained during exercise in men and women. Finally it was demonstrated that the sympathetic vasoconstriction in the exercising limb is similarly blunted in men and women. Overall, the results of this thesis suggest that there are no differences between men and women in baroreflex function and sympathetic vascular responsiveness during dynamic exercise.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: GV Recreation Leisure ; QP Physiology