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Title: Behavioural mechanisms underlying the effects the cannabinoid CB1 repector antagonist SR141716A on feeding
Author: Thornton-Jones, Zoe Diana
ISNI:       0000 0004 2718 1032
Awarding Body: University of Sussex
Current Institution: University of Sussex
Date of Award: 2004
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Little is known about the actions of the cannabinoid CB, receptor antagonist SR141716A on food intake and body weight, or the behavioural mechanisms that underlie these effects. The aim of the experiments presented in this thesis is to explore the influence of SR141716A on some of the signals that modulate feeding behaviour and help determine meal characteristics. These include: reward and motivational processes, hedonic processes and the development of satiety. Further experiments analysed interactions with serotonin, a neurotransmitter system important in appetite regulation, and effects on the adiposity signal adiponectin, which is involved in homeostatic control of energy balance. Using a novel operant schedule I studied the effects of SR141716A on reward processes initiated prior to and during feeding. These data are presented in chapter 2. Treatment with SR141716A suppressed both appetitive and consummatory components of feeding behaviour. This argues strongly for an involvement of SR141716A in the motivational aspects of consumption. Microstructural data presented in chapter 3 support this argument and suggest a role of the cannabinoid system in motivational processes associated with meal initiation änd satiation. In the experiments presented in chapter 4 differences between the effects of SR141716A on carbohydrate and fat diets are highlighted suggesting specific effects on fat consumption. Using both pharmacological tools and genetically modified animals, the experiments of chapter 5 investigated interactions between cannabinoids and serotonin, specifically, the CB1,5-HT, B and 5- HT2C receptors. The results revealed no functional interactions between the two systems with regards to feeding. The effects of chronic drug administration on body weight and food intake in an animal model of obesity, and the extent to which these effects were attributable to hypophagia, were determined and the data presented in chapter 6. Molecular biology techniques were employed to establish whether SR141716A acts on adipose tissue to modulate the adiposity signal Acrp30.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available