Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548489 |
![]() |
|||||||
Title: | Mechanisms of bacterial pathogenicity and of tissue localization | ||||||
Author: | Keppie, James |
ISNI:
0000 0004 2717 0392
|
|||||
Awarding Body: | University of Edinburgh | ||||||
Current Institution: | University of Edinburgh | ||||||
Date of Award: | 1965 | ||||||
Availability of Full Text: |
|
||||||
Abstract: | |||||||
Three contrasting examples of bacterial host-parasite relations were studied with a
view to recognising the compounds and processes responsible for the pathogenicity of
the causal organisms. In the belief that only bacteria collected from only the specific
disease-process in animals (i. e. An vivo) could be relied, on to have the complete
armoury of virulence factors, the three bacterial species selected: Bacillus anthracis, Pasteurella Westin and the calla group, were all initially grown in vivo. An adequate supply of such organisms was obtained, and fractionation studies of the
organisms and their products for substances responsible for virulence were made,
possible by the use of biological assays which simulated conditions in the host.
Once the important constituents of the bacteria grown in vivo had been recognised,it
was often possible to alter the culture conditions in vitro to produce bacteria
having the same constituents. The main findings were as follows-
Anthrax virulent organisms. had-to have two factors (1) the capsule of
polyglutamic acid which prevented opsonization and (2) the extracellular toxin, which was a mixture of three components, and poisoned the defence phagocytes: The massive
bactersomia found in dying guinea pigs was not essential for death.
|
|||||||
Supervisor: | Not available | Sponsor: | Not available | ||||
Qualification Name: | Thesis (D.Sc.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.548489 | DOI: | Not available | ||||
Share: |