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Title: Phenotypic characterisation of the C. elegans latrophilin homolog, lat-1
Author: Mestek, Lamia
ISNI:       0000 0004 2710 7000
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2011
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G proteins coupled receptors (GPCRs) play essential developmental roles with functions in all of the immune, olfactory sensory systems amongst other systems as well as exhibiting essential roles in the central and peripheral nervous system. GPCRs are also major targets of pharmaceutical drugs currently used to treat a vast number of conditions. Despite their clear importance, the function of many GPCRs is still obscure. Identifying the physiological role of more GPCRs provides a niche for more drugs to be developed and thus more conditions to be treated. The C.elegans lat-1 gene encodes the latrophilin vertebrate homolog; it is a member of the adhesion GPCR family and is structurally related to the flamingo/CELSR, an essential component of planar cell polarity pathway. This study aims to phenotypically characterise lat-1 mutants in C.elegans to provide insights into the physiological role of this important member of adhesion GPCRs. lat-1 mutants exhibit several morphological defects throughout development and during vulva development. Analysing the embryonic development of such mutants also identified an anterior-posterior polarity defect. The results implicate a second evolutionary conserved subfamily of adhesion GPCRs in the control of tissue polarity and morphogenesis.
Supervisor: Russ, Andreas Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Genetics (life sciences) ; Biochemistry ; genetics ; adhesion-GPCRs ; C. elegans ; polarity ; neurotransmission ; neuromuscular junctions ; egg laying ; cell division ; cell polarity ; latrophilin ; C. elegans morphogenesis