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Title: Peripheral mechanisms of inflammatory pain with particular reference to TRPV1, burn injury and the actions of certain gaseous general anaesthetics
Author: White, John P. M.
ISNI:       0000 0004 2703 581X
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2011
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In contrast, both anaesthetic gases (given for 60 min and without subsequent capsaicin injection) induced ERK1/2 activation in a different group of mainly lamina I neurons bilaterally. The total number of spinal dorsal horn neurons labelled on the ipsilateral side following capsaicin injection into the isoflurane-, or sevoflurane-, anaesthetised animals was significantly less than that produced by capsaicin alone. Further, capsaicin injection into isoflurane-, or sevoflurane-, anaesthetised animals reduced pERK1/2 induced by the gases alone on both sides. These key original findings are inconsistent with the suggestion that isoflurane-, or sevoflurane-, induced sensitisation of TRPV1 by capsaicin, or other agonist, is translated into induction of spinal nociceptive processing and consequential pain sensation.
Supervisor: Nagy, Istvan Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral