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Title: Self-assembly and bioinorganic chemistry of optically pure helical complexes
Author: Howson, Suzanne E.
ISNI:       0000 0004 2704 9293
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2011
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Chapter 1 introduces the concept of helicates and the importance of chirality in these complexes. The different literature methods used to synthesise optically pure helicates are reviewed and their advantages and disadvantages discussed. Finally, a new approach towards synthesising diastereomerically pure helicatelike complexes is considered. Chapter 2 describes the syntheses of optically and diastereomerically pure factris( diimine) monometallic complexes of Fe(II) with d.r. > 200:1. The origins of this unprecedented stereo- and chemical selectivity are investigated via computational and structural studies, and compared with analogous complexes of other 3d metals (ZnII, CoII, CoIII). The reactivity of the optically and stereochemically pure Fe(II) complexes towards e.g. copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition ‘click’ reactions is investigated. Recently published Cu(II) complexes of the same ligand by Min et al. are also discussed. Chapter 3 focuses on extending the chemistry described in Chapter 2 to design ligands capable of forming helicate-like structures. The resulting Fe(II) and Zn(II) bimetallic triple stranded complexes are diastereomerically pure with d.r. > 200:1. A detailed structural study is described based on a single crystal X-ray structure. The ability to add substituents to the pyridine rings successfully allows useful functionalities to be incorporated on the periphery of the structure. Chapter 4 describes the synthesis of a second family of diastereomerically pure helicate-like complexes. Useful functionalities are easily incorporated on the periphery of the structure via the use of different (R)-2-phenylglycinol derived amines in a one-pot synthesis. The reactivity of the alkyne hexa-functionalised Fe(II) complex towards copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition reactions is also investigated. Chapter 5 focuses on the synthesis and biological applications of water soluble helicate-like bimetallic complexes. Specifically, experiments probing the binding of these complexes to DNA and DNA structural motifs are described. The antimicrobial activity of the complexes against the Gram-negative bacterium E. coli and the Gram-positive bacterium S. aureus (MRSA252) is also investigated. Chapter 6 details the experimental procedures used to carry out the work in this thesis.
Supervisor: Not available Sponsor: Engineering and Physical Sciences Research Council (EPSRC)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry