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Title: Friction, wear, wear debris and functional biocompatibility of cartilage substitution biomaterials
Author: Russell, Serena Louisa
ISNI:       0000 0004 2703 4980
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2010
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The friction, wear and biological response to hydrogels, thermoset and thermoplastic polyurethanes were investigated in order to determine their suitability as potential cartilage substitution biomaterials. A single station pin-on-plate friction rig was utilised to determine the friction properties of these materials when articulated against articular cartilage plates and stainless steel plates. These materials were also reciprocated against stainless steel plates with smooth and rough surfaces using a six station multidirectional wear rig to generate clinically relevant sized wear particles which were characterised in terms of particle number and area as a function of size. Aseptically generated wear particles from the thermoset and thermoplastic polyurethanes were generated utilising a single station pin-on-plate wear rig and cultured with peripheral blood mononuclear cells to establish their biological activity by assessing the release of four cytokines (tumour necrosis factor-alpha, interleukin-lβ, interleukin-6 and interleukin-8) using an enzyme-linked immunosorbent assay. Friction tests demonstrated that articular cartilage (articulated against itself) exhibited a low coefficient of friction which was concurrent with the literature. The thermoplastic polyurethanes and hydrogels (against articular cartilage) exhibited statistically similar friction characteristics compared to articular cartilage against itself, however, the hydrogels generated considerable wear. In contrast, the friction characteristics of the thermoset polyurethanes were significandy higher than the friction of articular cartilage against itself. When wear particles were generated against stainless steel plates with smooth and rough surfaces, it was clear that the largest percentage number of particles were either < 0.1 or 0.1-1.0 11m in size, however, the percentage area of these particles was more variable and was either in the 0.1-1.0 μm, 1-10 μm or > 10 μm size range. Diprane SOD was the least biologically active material, as cells from two donors out of three were stimulated to release elevated levels of cytokines. Diprane SOD and Corethane 5SD were the only two materials to stimulate cells from donors to significandy release three cytokines out of four. All other materials stimulated an elevated level of all four cytokines from cells from all three donors.
Supervisor: Tipper, Joanne Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available