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Title: New organic and organometallic catalysts for asymmetric synthesis
Author: Manville, Charles
ISNI:       0000 0004 2700 4300
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2010
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Monodentate phosphorus ligands based on BINOL have been synthesised and applied to metal catalysed pressure hydrogenation and conjugate addition. Novel phosphorus containing enantioselective organocatalysts have been synthesised from DPEN and proline, and studied in the Michael addition of acetone to trans-β- nitrostyrenes, with up to 96 % e.e. The optimum reaction conditions for reaction rate and enantioselectivity have been investigated. Related proline-DPEN coupled organocatalysts have been synthesised and applied to the coupling reaction between DEAD and aldehydes. The proline-DPEN coupled compounds have been investigated for uses as ligands in the ruthenium catalysed asymmetric transfer hydrogenation of ketones in an aqueous medium. The hydrogenation reactions can be performed with good conversions and up to 98% e.e.
Supervisor: Not available Sponsor: Engineering and Physical Sciences Research Council (EPSRC) ; Rhodia (Firm)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry