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Title: Conserved and non-conserved functions of β-catenin in Metazoa
Author: Monaghan, John
ISNI:       0000 0004 2700 815X
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2010
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The conserved Metazoan protein β-catenin has important functions in both Wnt signalling and Cadherin-mediated adhesion. Tight regulation of β-catenin levels and location within cells is vital for the correct control of homeostasis, differentiation, morphogenesis and cell migration in developing and adult Metazoa. Misregulation of β- catenin leads to cells with altered proliferative and migratory properties and can lead to cancer. The Metazoan proteins BCL9 and Pygopus are important for the regulation of β- catenin and show different requirements in different organisms. β-catenin binds to BCL9, which binds to Pygopus. These interactions are thought to be involved in activation of Wnt signalling-dependent transcription, localisation of β-catenin and cross-talk between Wnt signalling and Cadherin-mediated adhesion. This thesis describes experiments using the frog Xenopus laevis to characterise the activities of carnosate, a small molecule inhibitor of the β-catenin-BCL9 interaction, and to assess its potential value as a drug for cancer therapy. More generally this thesis describes experiments undertaken towards a better understanding of how β-catenin links Wnt signalling and Cadherin-mediated adhesion and what role BCL9 and Pygopus play in this regard.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Metazoa