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Title: Reprogramming hepatocytes into duct-like cells
Author: O'Neill, Kathy
ISNI:       0000 0004 2693 280X
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2010
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Primary hepatocytes maintained in culture progressively down regulate liver-specific genes and lose their characteristic function and morphology. This process, termed dedifferentiation, is a hindrance to in vitro modelling of systems such as xenobiotic metabolism, liver disease and regeneration. However the results presented here demonstrate that dedifferentiated hapatocytes spontaneously induce expression of ductal genes, and therefore represent a useful model of cell reprogramming.
Supervisor: Slack, Jonathan ; Tosh, David Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: reprogramming ; liver ; transdifferentiation