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Title: Prediction of the biomechanical perfomance of a novel total disc replacement
Author: Falodi, Abiodun
ISNI:       0000 0004 2694 2282
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2010
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The pain experience as a result of disc degeneration disease (DDD) can be debilitating. When drug administration and physiotherapy treatment fail, surgical methods are used. These involve removal of the affected intervertebral disc IVD, followed by either decompression and fusion of the adjacent vertebral bodies or replacement of the removed IVD with an implant. Fusion is seen to be the gold standard for surgical treatment of DDD, but questions have been raised about its effectiveness in the long term due to its association with the adjacent levels disc degeneration. Disc replacement has been developed as an alternative to overcome this problem. The aim of the implant, in contrast to fusion, is the preservation of motion at the treated level. This has been said to maintain the adjacent level biomechanics and hence, prevent rapid degeneration. A novel graduated modulus polymeric total disc replacement device, Compliant Artificial Disc (CAdisc) developed by Ranier Technology Limited was studied in this project. Its design is such as to provide load-bearing capability and motion preservation at the implanted site. Through a unique manufacturing process, Precision Polyurethane Manufacturing PPM, the lower modulus ‘nucleus’ material of this device is encapsulated by the higher modulus ‘annulus’ with presence of graduated modulus in between. This project, aims to analyse the CAdisc mechanical properties and evaluate its biomechanical performance. Scanning Acoustic Microscope SAM and nano-indentation was used to analyse the CAdisc internal modulus distribution. The results show different modulus regions (the annulus, the graduated and the nucleus regions) in the CAdisc device and demonstrate the potential of the PPM process to produce consistent graduated region. It was also found that the SAM results were comparable to the nano-indentation with a significant correlation between the results. The technology in the development of the CAdisc-L (lumbar disc replacement) has been used to develop its cervical counterpart, CAdisc-C which is in its initial stage of design. Using a validated highly meshed 3D FEM of the cervical spine (C4-C7), developed from CT data, the biomechanical performance of cervical version of the CAdisc (CAdisc-C) was evaluated. The result shows the implant preserved motion at the treated level and gives a performance that preserved the biomechanics of the adjacent level compared to fusion. The study also shows that misplacement of the implant from its optimal position will not significantly affect its performance.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: R855 Medical technology. Biomedical engineering. Electronics