Use this URL to cite or link to this record in EThOS:
Title: A study on the application of independent component analysis to in vivo ¹H magnetic resonance spectra of childhood brain tumours for data processing
Author: Hao, Jie
ISNI:       0000 0004 2693 9892
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2010
Availability of Full Text:
Access from EThOS:
Access from Institution:
Independent component analysis (ICA) has the potential of automatically determining metabolite, macromolecular and lipid (MMLip) components that make up magnetic resonance (MR) spectra. However, the realiability with which this is accomplished and the optimal ICA approach for investigating in vivo MR spectra, have not yet been determined. A wavelet shrinkage de-noising based enhancement algorithm, utilising a newly derived relationship between the real and imaginary parts of the MR spectrum, is proposed. This algorithm is more robust compared with conventional de-noising methods. The two approaches for applying ICA, blind source separation (BSS) and feature extraction (FE), are thoroughly examined. A feature dimension selection method, which has not been adequately addressed, is proposed to set a theoretical guideline for ICA dimension reduction. Since the advantages and limitations of BSS-ICA and FE-ICA are different, combining them may compensate their disadvantages and lead to better results. A novel ICA approach involving a hybrid of the two techniques for automated decomposition of MRS dataset is proposed. It has been demonstrated that hybrid ICA provides more realistic individual metabolite and MMLip components than BSS-ICA or FE-ICA. It can aid metabolite identification and assignment, and has the potential for extracting biologically useful features and discovering biomarkers.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: TK Electrical engineering. Electronics Nuclear engineering