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Title: Patterns of radiographic hand osteoarthritis and associations with pain and function : a prospective cohort study
Author: Marshall, Michelle
ISNI:       0000 0004 2695 2026
Awarding Body: Keele University
Current Institution: Keele University
Date of Award: 2010
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Radiographic hand osteoarthritis (OA) affects a large number of older people and can lead to significant pain and disability. Patterns of radiographic hand OA and associations with pain and function have not being studied in detail. A systematic search and review was undertaken to determine methods used to examine radiographic hand OA. The thumb interphalangeal joint was infrequently studied and inconsistently grouped with other hand joints. The Kellgren and Lawrence grading system was the most frequently used to assess and define hand OA within published communitybased epidemiological studies. Community-dwelling adults (z50 years) who had experienced hand pain or hand problems in the previous year were recruited to a cohort, the Clinical Assessment Study of the Hand (n=623). Presence of hand OA was assessed on radiographs using the Kellgren and Lawrence grading system. Patterns of radiographic OA in the hand joints were investigated and analysis identified that the finger joints grouped by rows whilst the four joints of the thumb grouped together as a ray. The location of radiographic OA in the hand and its contribution to hand pain and functional limitation were explored. Participants with combined radiographic finger and thumb OA had more pain and functional limitation than individuals with thumb or finger OA alone. Further study of the thumb found associations between thumb pain, thenar muscle wasting, presence of nodes, deformity or enlargement and the presence of radiographic thumb OA. Ei]The course of radiographic hand OA over time was examined. Almost half the individuals reported deterioration in their hand problem, and small increases in hand pain and functional limitation were seen at 18 months and 3 years. Poorer overall physical functioning was found in the combined finger and thumb OA sub-group at baseline. However, over a3 year period very little change was seen in overall physical functioning or general health
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available