Continuous advances in science and technology, and developments in clinical and public health are leading to improvements in the quality of life and longevity. Many diseases have been found to be curable or controlled very well by treatments. However, there are still some diseases which are not treatable or are age-related degenerative diseases such as heart disease and cancer. Cancer is a disease of complex aetiology and there is still much to be studied and understood. In this study the impact of inflammation on melanoma migration, invasion and survival was studied in a simple 2D model and in an engineered human skin model.