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Title: Attenuation of quorum sensing using computationally designed polymers
Author: Stavroulakis, Georgios
ISNI:       0000 0004 2690 012X
Awarding Body: Cranfield University
Current Institution: Cranfield University
Date of Award: 2010
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It is generally accepted that the majority of Gram-negative and Gram-positive bacteria communicate via production and sensing of small signal molecules, autoinducers. The ability of bacteria to sense their population density is termed quorum sensing (QS). Quorum sensing controls certain phenotypic traits, particularly virulence factors and biofilm formation. In this project a new solution for the attenuation of quorum sensing which involves selective sequestering of the signal molecules using rationally designed synthetic polymers was explored.
Supervisor: Piletsky, Sergey ; Tothill, I. E. ; Piletsky, E. ; Robinson, G. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available